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Sapropterin reduces coronary artery malformation in offspring of pregestational diabetes mice.
Engineer A, Lim YJ, Lu X, Kim MY, Norozi K, Feng Q. Engineer A, et al. Nitric Oxide. 2020 Jan 1;94:9-18. doi: 10.1016/j.niox.2019.10.002. Epub 2019 Oct 7. Nitric Oxide. 2020. PMID: 31600600
The aim of the present study was to examine the effects of sapropterin on fetal coronary artery development during pregestational diabetes in mice. Diabetes was induced by streptozotocin to adult female C57BL/6 mice. Sapropterin (10 mg/kg/day) was orally administered to pr …
The aim of the present study was to examine the effects of sapropterin on fetal coronary artery development during pregestational diabetes i …
Disturbance of retinol transportation causes nitrofen-induced hypoplastic lung.
Nakazawa N, Montedonico S, Takayasu H, Paradisi F, Puri P. Nakazawa N, et al. J Pediatr Surg. 2007 Feb;42(2):345-9. doi: 10.1016/j.jpedsurg.2006.10.028. J Pediatr Surg. 2007. PMID: 17270546
Reverse transcriptase-polymerase chain reaction was performed to evaluate the relative amount of cellular retinol-biding protein I, retinal dehydrogenase 1a2 and 1a3 (Aldh1a2 and Aldh1a3), retinoic acid receptors alpha and beta (RARalpha, RARbeta), and retinoid X receptor …
Reverse transcriptase-polymerase chain reaction was performed to evaluate the relative amount of cellular retinol-biding protein I, retinal …
Identification and functional analysis of novel facial patterning genes in the duplicated beak chicken embryo.
Nimmagadda S, Buchtová M, Fu K, Geetha-Loganathan P, Hosseini-Farahabadi S, Trachtenberg AJ, Kuo WP, Vesela I, Richman JM. Nimmagadda S, et al. Dev Biol. 2015 Nov 15;407(2):275-88. doi: 10.1016/j.ydbio.2015.09.007. Epub 2015 Sep 16. Dev Biol. 2015. PMID: 26385749 Free article.
We tested the functional effects of PI15 overexpression with a retroviral misexpression strategy. PI15 virus induced a cleft beak analogous to human cleft lip. We next asked whether PI15 effects were mediated by changes in expression of major clefting genes and genes in th …
We tested the functional effects of PI15 overexpression with a retroviral misexpression strategy. PI15 virus induced a cleft beak ana …
Altered regulation of retinoic acid synthesis in nitrofen-induced hypoplastic lung.
Nakazawa N, Takayasu H, Montedonico S, Puri P. Nakazawa N, et al. Pediatr Surg Int. 2007 May;23(5):391-6. doi: 10.1007/s00383-006-1848-8. Pediatr Surg Int. 2007. PMID: 17203325
Down-regulation of Cryp26b1 and LRAT demonstrates that RA content is decreased in nitrofen induced hypoplastic lungs compared to controls. The finding that RALDH2 expression in the hypoplastic lung is not altered suggests that nitrofen may act by interfering with the retin …
Down-regulation of Cryp26b1 and LRAT demonstrates that RA content is decreased in nitrofen induced hypoplastic lungs compared to cont …
Ethanol induces embryonic malformations by competing for retinaldehyde dehydrogenase activity during vertebrate gastrulation.
Kot-Leibovich H, Fainsod A. Kot-Leibovich H, et al. Dis Model Mech. 2009 May-Jun;2(5-6):295-305. doi: 10.1242/dmm.001420. Epub 2009 Apr 6. Dis Model Mech. 2009. PMID: 19380308 Free PMC article.
In alcohol-treated embryos, we analyzed RA signaling levels, phenotypes induced and changes in gene expression. Developmental defects that were characteristic of high ethanol concentrations were phenocopied by a low ethanol concentration combined with partial RALDH inhibit …
In alcohol-treated embryos, we analyzed RA signaling levels, phenotypes induced and changes in gene expression. Developmental defects …